Journal
\nof Hazardous Materials<\/i><\/a>, an international scientific journal.<\/p>\n\u00a0<\/p>\n
Association between BPS and breast cancer
\nunder-researched<\/b><\/p>\n
\u00a0<\/p>\n
In
\nthe past, bisphenol A (BPA) was widely used in the production of a diverse
\nrange of products, such as baby bottles, food and beverage containers, and the
\nthermal paper used for printing receipts. As previous research has shown an
\nassociation between BPA exposure and human endocrine system disruption, metabolic
\ndisease and an increased risk of breast cancer in recent years, scientists have
\nlooked for alternatives to BPA, and BPS has been used as one of the
\nsubstitutes. Despite reports on the adverse effects of BPS on human health, its
\nimpact on tumour progression and how it disrupts the relevant metabolic
\nprocesses in breast cancer remain poorly understood.<\/p>\n
\u00a0<\/p>\n
A
\nresearch team led by Professor Cai
\nZongwei, Chair Professor of the Department of Chemistry and Director of the
\nState Key Laboratory of Environmental and Biological Analysis at HKBU<\/b>,
\ncarried out several experiments to explore how BPS exposure at environmentally
\nrelevant levels affects the development of breast tumours, including the
\ntumour’s morphological characteristics as well as lipid and protein
\ndistribution, with the aid of mass spectrometry imaging technology.<\/p>\n
\u00a0<\/p>\n
BPS
\nexposure increases tumour volume and weight<\/b><\/p>\n
\u00a0<\/p>\n
The
\nresearch team conducted experiments on three groups of mice model that had been
\ntransplanted with human breast cancer cells. In the first dosing group (BPS-10
\ngroup), the mice were fed daily with a lower dosage of 10 micrograms of BPS per
\nkilogram of body weight for eight weeks. In the second group (BPS-100 group),
\nthe mice were fed with a higher dosage of 100 micrograms of BPS per kilogram of
\nbody weight. The mice in the control group were fed olive oil.<\/p>\n
\u00a0<\/p>\n
Tumour
\nproliferation in the mice was then investigated, and the team used
\nmorphological analysis to study the breast tumour tissue. In general, increases
\nin tumour volume and weight represent proliferation of tumour tissues. When a
\ntumour further develops, the condition of its necrotic region and its
\nperipheral tissues will change. However, the volume and weight of the tumour
\nmay reduce as a result of changes in the conditions of the tissues.<\/p>\n
\u00a0<\/p>\n
After
\nthe eight-week experiment, the average volume and weight of the tumours in the
\nBPS-10 group were 13 times and 11 times higher than that of the control group
\nrespectively, and the average volume and weight of the tumours in the BPS-100
\ngroup were 4 times and 4.5 times higher than that of the control group
\nrespectively. Therefore, the results show that exposure to BPS was closely related to the proliferation and
\ndeterioration of breast tumours<\/b>. <\/p>\n
\u00a0<\/p>\n
Different dosages associated with tumour
\nproliferation and deterioration<\/b><\/p>\n
\u00a0<\/p>\n
The research team analysed the necrotic
\nregion and neoplastic region of the breast tumours in the three groups of mice.
\nThe two regions are common pathological features of solid tumours. An increase
\nin the relative proportion of the necrotic region reflects the proliferation of
\nthe tumour, while an extended neoplastic region indicates the deterioration of
\nthe tumour.<\/p>\n
\u00a0<\/p>\n
In
\nthe control group, the status of tumour cells in the necrotic region and the
\nneoplastic region was stable, and the mice from the group showed no significant
\ntumour proliferation and deterioration after the experimental period. However, in the two BPS treated groups, an increase
\nin tumour size was observed along with changes in the arrangement and
\ndistribution of tumour cells conducive to tumour proliferation and
\ndeterioration<\/b>. <\/p>\n
\u00a0<\/p>\n
After
\nthe experiment, the necrotic regions in the BPS-10 and the BPS-100 groups
\naccounted for 54.7% and 11.5% of the average section area of the tumours
\nrespectively. The results indicate that a
\nlow dosage of BPS induces faster tumour growth, and<\/b> a high dosage of BPS may ultimately lead to deterioration of the tumour<\/b>,
\nas shown by the relatively small average size of the necrotic region and the
\nextended neoplastic tissue in the BPS-100 group.<\/p>\n
\u00a0<\/p>\n
BPS affects the distribution of tumour-related
\nlipids and proteins<\/b><\/p>\n
\u00a0<\/p>\n
The
\nresearch team identified six lipid biomarkers that regulate tumour growth. With
\nthe analysis of tumour tissues’ morphological characteristics and the use of
\nmass spectrometry imaging, it was found that in the two BPS-exposed groups,
\nthese lipids were highly abundant in the necrotic regions of breast tumours
\nwhen compared with the control group. The team inferred that the metabolism of these tumour-regulating
\nlipids was interrupted in the breast tumours following exposure to BPS<\/b>. <\/p>\n
\u00a0<\/p>\n
The
\nteam also discovered the distribution of twelve protein biomarkers, including
\nthe proteins associated with breast tumour proliferation and deterioration. The results demonstrate the important
\nfunction of BPS exposure-related lipids and proteins, and future research will
\nfurther explore their role in breast cancer. <\/b><\/p>\n
\u00a0<\/p>\n
BPS may increase human breast cancer risk<\/b><\/p>\n
\u00a0<\/b><\/p>\n
The
\nresearch team then compared the distribution of lipids and proteins in the
\nBPS-exposed mice groups with those observed in human breast cancer tissue
\nsamples, and similar patterns were identified. While not all tumours will
\nbecome cancerous, based on the benchmark results, the team deduced that exposure to BPS will increase the risk of breast
\ncancer in humans<\/b>. <\/p>\n
\u00a0<\/p>\n
“BPA
\nwas replaced by the less studied chemical BPS in industrial production. Our
\nresearch findings show that BPS may potentially be associated with breast tumour proliferation, and
\nfurther study is deemed necessary to unveil more about the chemical’s possible
\nnegative impact on human health. In the long run, industry may need to identify
\nsafer substitutes for both BPA and BPS. Policymakers should also establish
\nrelevant safety standards and regulations for the use of BPS,” said
\nProfessor Cai.<\/p>\n
#HongKongBaptistUniversity #HKBU<\/p>\n<\/p><\/div>\n\n
Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"HONG KONG SAR – Media OutReach – 18 January 2022 – A study led by Hong Kong Baptist University (HKBU) has revealed that different degrees of exposure to bisphenol S (BPS), an industrial chemical widely used in paper products and plastic containers, are associated with the growth and deterioration of breast tumours in a mouse …<\/p>\n","protected":false},"author":1,"featured_media":20005,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[60],"tags":[],"_links":{"self":[{"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/posts\/20004"}],"collection":[{"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/comments?post=20004"}],"version-history":[{"count":0,"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/posts\/20004\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/media\/20005"}],"wp:attachment":[{"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/media?parent=20004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/categories?post=20004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eodishasamachar.com\/en\/wp-json\/wp\/v2\/tags?post=20004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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